«Smart Sleep» Laboratory

The group of neurophysiologists is focused on the study of functions of the cerebral lymphatic system and development the new methods for real-time monitoring and analysis of lymphatic drainage and clearing of the human and anamial brain using two-photon, confocal and electron microscopy, magnetic resonance imaging, electroencephalography, histological and morphological approaches.

In clinical studies using modern technologies for visualization of brain structures, the lymphatic processes of removing toxins from the central nervous system are studied. Pioneering technologies are being developed for modulating lymphatic processes of elimination of blood from brain in newborns and beta-amyloid in patients with Alzheimer's disease.

A model-theoretical analysis of the movement of brain fluids through the lymphatic vessels and the dependence of these processes on the state of wakefulness and sleep is carried out.

We develop pioneering technologies for in vivo visualization of transparent lymphatic vessels of the brain and its meninges, as well as for real-time monitoring of the lymphatic drainage of the brain in rodents using multiphoton, fluorescence microscopy and optical coherence tomography.

This group develops breakthrough technologies for identification of "therapeutic sleep windows" in order to diagnose the permability of the blood-brain barrier and to control the lymphatic drainage processes of removing toxins from brain using nonlinear EEG analysis and machine learning approaches.